A CE Marked In Vitro Diagnostic.
Resistance of influenza virus to antivirals has been a significant problem in the past. Circulating influenza viruses are normally resistant to older antivirals amantadine and rimantadine. And, resistance to newer antiviral drugs had appeared. For example, most seasonal H1N1 flu virus isolates circulating in U.S. in 2008/2009 were resistant to Tamiflu®.
For Research Use Only in U.S.
The QFlu Combo Test is intended for rapid and simultaneous detection of Type A and B influenza virus and its susceptibility to Tamiflu®. The test is simple, easy-to-use, rapid (about 15 minutes), and sensitive. When used with the Helios 200 Analyzer, the analyzer can detect the signal and automatically interpret the test results.
The QFlu Combo Test detects the enzymatic activity of influenza viral neuraminidase, which is also the target of a new generation of anti-influenza drugs such as Tamiflu® and Relenza®. Thus, the influenza virus and its susceptibility to these drugs can be detected in a single assay.
The QFlu Combo Test uses two reagents, QFlu Reagents I and II. The signal from QFlu Reagent I is used for diagnosis of influenza while the signal ratio of QFlu Reagent II to I is used to indicate susceptibility of the flu virus to Tamiflu®. The sensitivity and specificity for influenza diagnosis are the same as the QFlu Dx Test. The signal ratio of QFlu Reagent II to Reagent I is highly correlated to IC50 of the virus, a commonly used parameter to indicate resistance or susceptibility to a neuraminidase inhibitor.
The QFlu Combo Test contains the following components, please use 1X Q-Sample Buffer as the negative control: